Version: 8.0.0
Date: Tue Jan 28 2025
Npntem1(flpo)Ngai
MGI:6865658
Allele of Npnt
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Npntem1(flpo)Ngai

Species
Mus musculus
Symbol
Npntem1(flpo)Ngai
Category
allele
Allele of gene
Npnt
Transgenic Constructs
Synonyms
None
Description
Using CRISPR/Cas9 technology, the P2A-FlpO sequence (encoding a viral 2A oligopeptide that mediates ribosomal skipping and a codon-optimized FLPe gene modified for translation in mammalian cells and higher recombination efficiency in cells and in mice) was inserted after the STOP codon of the nephronectin gene (Npnt) on chromosome 3 in v6.5 embryonic stem (ES) cells. Chimeric mice were generated by aggregating ES cells with morula-stage embryos.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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