P2rx2^em1Xzl

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Species

Mus musculus

Symbol

P2rx2^em1Xzl

Category

allele

Allele of gene

P2rx2

Transgenic Constructs

None

Synonyms

• P2rx2 c.179GC
• P2rx2 KI

Show All 3

Description

Using sgRNA (targeting GCACGATGAAGACGTACCTG) and an ssODN template with CRISPR/Cas9 technology, valine codon 61 (GTC) in exon 2 was changed to leucine (CTC) (c.181G>C, p.V61L). This mutation mimics the human p.V60L mutation associated with a form of dominant early-onset progressive sensorineural hearing loss (DFNA41).

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations