Allele/Variant

Agmotm2a(EUCOMM)Wtsi

Species
Mus musculus
Symbol
Agmotm2a(EUCOMM)Wtsi
Category
allele
Allele of gene
Agmo
Transgenic Constructs
None
Synonyms
  • Agmo-lacZ tg
Description
The L1L2_Bact_P cassette was inserted at position 37293227 of Chromosome 12 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 37294023. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml The targeting event produced an unintended duplication of a 94 kb genomic region encompassing exons 1 through 3.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
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