Allele/Variant

4933425B07RikTn(pb-Act-RFP)1.1Zhu

Species
Mus musculus
Symbol
4933425B07RikTn(pb-Act-RFP)1.1Zhu
Category
allele
Allele of gene
4933425B07Rik
Transgenic Constructs
None
Synonyms
  • RikPB
Description
The transposon containing an unspecified hybrid actin promoter driving expression of red fluorescent protein (RFP) flanked by piggyBac-specific left and right terminal sequences was co-injected with a piggyBac-containing transgene to mobilize the transposon. The transposon inserted into intron 3 of the gene, resulting in overexpression in homozygous mutant mice. RT-PCR of whole embryos and embryonic kidneys of E12.5 homozygous and heterozygous mice detected an increase in expression levels compared to that in wild type mice.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal kidney morphologyMGI
abnormal metanephric ureteric bud developmentMGI
abnormal renal/urinary system morphologyMGI
decreased renal glomerulus numberMGI
decreased renal tubule numberMGI
duplex kidneyMGI
hydronephrosisMGI
impaired branching involved in ureteric bud morphogenesisMGI
renal hypoplasiaMGI
vesicoureteral refluxMGI
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Disease Associations

No data available