Allele/Variant

Serpina3cem1Smoc

Species
Mus musculus
Symbol
Serpina3cem1Smoc
Category
allele
Allele of gene
Serpina3c
Transgenic Constructs
None
Synonyms
  • SERPINA3C-KO
Description
CRISPR/Cas9 technology was used to delete exons 2-5 of the mouse Serpina3c gene by non-homologous recombination. qPCR analysis demonstrated that mRNA expression was abolished in multiple tissues, including brown adipose tissue (BAT), inguinal and epididymal white adipose tissue (WAT), liver, and muscle. Western blot analysis confirmed the absence of protein expression in the inguinal and epididymal WAT of homozygous mutant mice.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations