Pold4^em1Zzho

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Species

Mus musculus

Symbol

Pold4^em1Zzho

Category

allele

Allele of gene

Pold4

Transgenic Constructs

None

Synonyms

None

Description

CRISPR/Cas9 technology generated a 744 bp deletion encompassing exon 2 and 3, resulting in a frameshift and theoretically should produce a 52-amino acid mutant protein, however nonsense-mediated mRNA decay should be triggered and result in degradation of the mRNA and thus loss of function. Western blot analysis confirmed absence of protein in various tissues including spleen, lung, liver, kidney, testis and ovary.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations