Version: 8.0.0
Date: Tue Jan 28 2025
Trim28tm1.1Ics
MGI:7471137
Allele of Trim28
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Trim28tm1.1Ics

Species
Mus musculus
Symbol
Trim28tm1.1Ics
Category
allele
Allele of gene
Trim28
Transgenic Constructs
None
Synonyms
  • Trim28C651F
  • Trim28PHD
Description
Cysteine codon 651 (TGC) in exon 13 was changed to phenylalanine (TTT) (p.C651F) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 3. The neo cassette was removed through subsequent Cre-mediated recombination. The mutation is located in the PHD domain of the encoded peptide and abrogates its SUMO-E3-ligase activity.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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