Version: 8.0.0
Date: Tue Jan 28 2025
Myh11em1(icre)Jifz
MGI:7512809
Allele of Myh11
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Myh11em1(icre)Jifz

Species
Mus musculus
Symbol
Myh11em1(icre)Jifz
Category
allele
Allele of gene
Myh11
Transgenic Constructs
Synonyms
  • Myh11-CreNLSP2A
  • Myh11em1(cre)Jifz
Description
Using CRISPR/Cas9 technology, a a nuclear localization sequence (NLS) followed by a codon optimized Cre recombinase fused to ERT2, a GSG linker and a P2A peptide (for production of a bicistronic mRNA transcript) immediately was inserted into the endogenous Myh11 gene immediately after the first codon ATG in exon 2. Cre expression is constitutive rather than inducible by tamoxifen.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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