Tmem161b^em2Jgg

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Species

Mus musculus

Symbol

Tmem161b^em2Jgg

Category

allele

Allele of gene

Tmem161b

Transgenic Constructs

None

Synonyms

• W317R-KI

Description

Tryptophan codon 317 (TGG) in exon 10 was changed to arginine (CGT) (c.949_951delTGGinsCGT, p.W317R) using an sgRNA (targeting CATTTGATACTCTTCGACTC) and an ssODN template with CRISPR/Cas9 technology. The mutation is the equivalent of the human c.949C>T:p.W317R mutation associated with polymicrogyria (PMG).

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations