Version: 8.0.0
Date: Tue Jan 28 2025
Bdnftm1.1Tmiz
MGI:7545595
Allele of Bdnf
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Bdnftm1.1Tmiz

Species
Mus musculus
Symbol
Bdnftm1.1Tmiz
Category
allele
Allele of gene
Bdnf
Transgenic Constructs
None
Synonyms
  • BDNFpro
Description
The coding region in the last exon was replaced with the same fragment coding for a cleavage-resistant form with p.R135M (c.404G>T) and p.R137L (c.410G>T) mutations, and a loxP site flanked neomycin resistance gene cassette was inserted downstream of the gene. The neo cassette was removed through subsequent Cre-mediated recombination. The mutations, close to the encoded peptide cleavage site, affect proteolytic cleavage of the prodomain that is necessary to form the mature peptide. They mimic the human tandem SNPs c.374G>T (rs1048220) and c.380G>T (rs1048221).
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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