Version: 8.0.0
Date: Tue Jan 28 2025
Sqstm1em1Kmts
MGI:7570167
Allele of Sqstm1
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Sqstm1em1Kmts

Species
Mus musculus
Symbol
Sqstm1em1Kmts
Category
allele
Allele of gene
Sqstm1
Transgenic Constructs
None
Synonyms
  • p62S351E
Description
Serine codon 351 (TCT) was changed to glutamic acid (GAG) (p.S351E) using a pegRNA (containing target-binding sequence GACUGGAGUUCACCUGUAGA and template GUGGACCCAGAG) with the prime editing system. The mutation replaces a phosphorylatable residue in the encoded peptide with a phosphomimetic, rendering the peptide permanently activated.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
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