Crx^em2Smgc

---

Species

Mus musculus

Symbol

Crx^em2Smgc

Category

allele

Allele of gene

Crx

Transgenic Constructs

None

Synonyms

• Crx^K88N

Description

Lysine codon 88 (AAG) in exon 4 was changed to asparagine (AAC) (p.K88N) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation, in the homeodomain (HD) of the encoded peptide, is the equivalent of same human mutation associated with dominant Leber congenital amaurosis 7 (LCA7).

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations