Allele/Variant

Ido2em2Lamn

Species
Mus musculus
Symbol
Ido2em2Lamn
Category
allele
Allele of gene
Ido2
Transgenic Constructs
None
Synonyms
  • IDO2 Y346X
Description
Tyrosine codon 346 (TAC) in exon 10 was changed to a stop codon (TAA) (p.Y346*) using sgRNAs (targeting ATCTGGCCACGACATTGATGTGG and CAGTTACCACATCAATGTCGTGG) and an ssODN template with CRISPR/Cas9 technology. The mutation is the equivalent of common human SNP rs4503083 (p.Y359*) that creates a KO allele. No protein expression was detected in the liver.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations