Version: 8.0.0
Date: Tue Jan 28 2025
Chrna2tm1.1Slot
MGI:7621414
Allele of Chrna2
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Chrna2tm1.1Slot

Species
Mus musculus
Symbol
Chrna2tm1.1Slot
Category
allele
Allele of gene
Chrna2
Transgenic Constructs
None
Synonyms
  • Chrna2L9'S
Description
Leucine codon 282 (CTC) in exon 5 was changed to serine (AGC) (p.L282S) and an FRT site flanked neomycin resistance gene cassette was inserted into intron 4. The neo cassette was removed through subsequent Flp-mediated recombination. The mutation, at Leu 9' in the transmembrane region 2 (TM2) of the encoded peptide, modifies the physiological response of the receptor to nicotine and acetylcholine.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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