Version: 8.0.0
Date: Tue Jan 28 2025
Camk2dem1Mean
MGI:7628184
Allele of Camk2d
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Camk2dem1Mean

Species
Mus musculus
Symbol
Camk2dem1Mean
Category
allele
Allele of gene
Camk2d
Transgenic Constructs
None
Synonyms
  • CaMKIIdeltaM308V
Description
Methionine codon 308 (ATG) in exon 12 was changed to valine (GTG) (p.M308V) using an sgRNA (equivalent to CGCCATCTTGACAACTATGCTGG) and an ssODN template with CRISPR/Cas9 technology. The mutation, in the calmodulin-binding domain of the encoded peptide, reduces calmodulin binding and kinase activity.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
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