Allele/Variant

bns35

Species
Danio rerio
Symbol
bns35
Category
allele
Allele of gene
wwtr1
Transgenic Constructs
None
Synonyms
None
Description
Not Available
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

NC_007133.7:g.38094220_38094221insGAAGTCTACCGAAGAGCCCCAGGAAGTCC

Symbol
NC_007133.7:g.38094220_38094221insGAAGTCTACCGAAGAGCCCCAGGAAGTCC
Category
Variant
Variant type
insertion
Overlaps
wwtr1
Location
22:38094220-38094221
Nucleotide Change
>cGAAGTCTACCGAAGAGCCCCAGGAAGTCC
Most Severe Consequence
  • frameshift variant
See all consequences
HGVS.g name
  • NC_007133.7:g.38094220_38094221insGAAGTCTACCGAAGAGCCCCAGGAAGTCC
  • 22:g.38094220_38094221insGAAGTCTACCGAAGAGCCCCAGGAAGTCC
HGVS.c name
  • ENSEMBL:ENSDART00000097533.1:c.434_435insGAAGTCTACCGAAGAGCCCCAGGAAGTCC
HGVS.p name
  • :p.Arg146LysfsTer14
Synonyms
Not Available
Notes
  • The bns35 allele has a 29 bp insertion in exon 2 of the wwtr1 gene. This out-of-frame insertion is predicted to cause the production of a truncated protein (p.Pro145Glnfs*15).
Cross references
Not Available
References
All alleles with this variant

Genome location
Assembly version
GRCz11
Viewer Help
38.05M38.06M38.07M38.08M38.09M38.10M38.11M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.

Variant Molecular Consequences

Predicted effect of NC_007133.7:g.38094220_38094221insGAAGTCTACCGAAGAGCCCCAGGAAGTCC

Variant
NC_007133.7:g.38094220_38094221insGAAGTCTACCGAAGAGCCCCAGGAAGTCC
Variant type:
insertion
Sequence feature
Sequence feature type
Associated gene
Location
Molecular consequence
Codon and amino acid change
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    Phenotypes

    Phenotype
    Annotation details
    Source
    References
    cardiac ventricle trabecula formation decreased process quality, abnormal
    ZFIN
    compact layer of ventricle cell junction oblique orientation, abnormal
    ZFIN
    compact layer of ventricle cortical actin cytoskeleton GFP expression spatial pattern, abnormal
    ZFIN
    compact layer of ventricle cortical actin cytoskeleton malformed, abnormal
    ZFIN
    compact layer of ventricle has normal numbers of parts of type cardiac muscle cell, normal
    ZFIN
    ectoderm wwtr1 expression absent, abnormal
    ZFIN
    notochord wwtr1 expression absent, abnormal
    ZFIN
    trabecular layer of ventricle has normal numbers of parts of type cardiac muscle cell, normal
    ZFIN
    trabecular layer of ventricle lacks parts or has fewer parts of type cardiac muscle cell, abnormal
    ZFIN
    trabecular layer of ventricle malformed, abnormal
    ZFIN
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    Disease Associations

    No data available