Version: 8.0.0
Date: Tue Jan 28 2025
BN2 diffuse large B-cell lymphoma
DOID:0081064
SummaryAssociated GenesAssociated AllelesAssociated Models
Disease

BN2 diffuse large B-cell lymphoma

Definition
A diffuse large B-cell lymphoma that is categorized as BN2 with high probability by the LymphGen algorithm. This is based on a combination of genetic features and BN2 DLBCLs often, but do not always, have a translocation involving the BCL6 locus and/or some combination of mutations affecting NOTCH2, TNFAIP3, BCL10 and UBE2A. This subgroup also commonly has mutations due to aberrant somatic hypermutation affecting CD70, which can be coding or non-coding.
Synonyms
  • BN2 DLBCL
Cross References
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Sources of Associations

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