Enables mRNA 3'-UTR binding activity. Involved in several processes, including female germ-line stem cell population maintenance; positive regulation of exit from mitosis; and regulation of gene expression. Located in P granule; nuclear body; and nuclear membrane. Is expressed in several structures, including adult head; embryonic anal pad; flight muscle cell; germline cell; and gonad. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 97. Orthologous to human CELF1 (CUGBP Elav-like family member 1) and CELF2 (CUGBP Elav-like family member 2).
FB Description
bruno 1 (bru1) encodes an RNA binding protein acting in multiple forms of post-transcriptional gene regulation including repression and activation of translation and alternative splicing of pre-mRNAs. The product of bru1 is required for gametogenesis, developmental patterning, and muscle organization.