Gene

bru1

Species
Drosophila melanogaster
Symbol
bru1
Name
bruno 1
Synonyms
  • aret
  • ARET
Biotype
protein coding gene
Automated Description
Enables mRNA 3'-UTR binding activity. Involved in several processes, including female germ-line stem cell population maintenance; positive regulation of exit from mitosis; and regulation of gene expression. Located in P granule; nuclear body; and nuclear membrane. Is expressed in several structures, including adult head; embryonic anal pad; flight muscle cell; germline cell; and gonad. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 97. Orthologous to human CELF1 (CUGBP Elav-like family member 1) and CELF2 (CUGBP Elav-like family member 2).
FB Description
bruno 1 (bru1) encodes an RNA binding protein acting in multiple forms of post-transcriptional gene regulation including repression and activation of translation and alternative splicing of pre-mRNAs. The product of bru1 is required for gametogenesis, developmental patterning, and muscle organization.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24012
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
12.18M12.20M12.22M12.24M12.26M12.28M12.30M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions