Gene

ben

Species
Drosophila melanogaster
Symbol
ben
Name
bendless
Synonyms
  • anon-WO03040301.242
  • BEN
Biotype
protein coding gene
Automated Description
Enables ubiquitin conjugating enzyme activity; ubiquitin conjugating enzyme binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including grooming behavior; nervous system development; and positive regulation of signal transduction. Located in nucleus and perinuclear region of cytoplasm. Part of UBC13-MMS2 complex. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; ganglia; and gut section. Orthologous to human UBE2N (ubiquitin conjugating enzyme E2 N) and UBE2NL (ubiquitin conjugating enzyme E2 N like (gene/pseudogene)).
FB Description
bendless (ben) encodes an E2 ubiquitin-conjugating enzyme. It plays essential roles in multiple processes such as synaptic growth and maturation, axon guidance, innate immunity, genomic integrity, tumor growth, cell invasion, apoptosis, long-term memory and escape response.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24068
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
13.9965M13.9970M13.9975M13.9980M13.9985M13.9990M13.9995M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions