Version: 8.0.0
Date: Tue Jan 28 2025
by
Drosophila melanogasterFB:FBgn0000244
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

by

Species
Drosophila melanogaster
Symbol
by
Name
blistery
Synonyms
  • 3R-B
  • BcDNA:RE65113
Biotype
protein coding gene
Automated Description
Enables actin filament binding activity; cytoskeletal protein-membrane anchor activity; and phosphotyrosine residue binding activity. Involved in apposition of dorsal and ventral imaginal disc-derived wing surfaces and positive regulation of cell-cell adhesion mediated by integrin. Located in focal adhesion. Is expressed in several structures, including adult heart; foregut primordium; gut section; keyhole structure; and organism subdivision. Orthologous to several human genes including TNS1 (tensin 1).
FB Description
blistery (by) encodes fly tensin, an adaptor protein that can bind integrins and actin and colocalizes with integrins in numerous tissues. Null alleles have a mild defect in integrin adhesion, as they are adult viable with loss of adhesion between the wing epithelia.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45734
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            Data currently unavailable; sequence viewer under construction

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

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            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

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              by genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
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