Version: 8.0.0
Date: Tue Jan 28 2025
Cam
Drosophila melanogasterFB:FBgn0000253
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Cam

Species
Drosophila melanogaster
Symbol
Cam
Name
Calmodulin
Synonyms
  • 3909
  • anon-EST:Posey59
Biotype
protein coding gene
Automated Description
Enables calcium ion binding activity; channel regulator activity; and myosin binding activity. Involved in several processes, including autophagic cell death; cellular response to ethanol; and neuron development. Located in several cellular components, including microtubule cytoskeleton; midbody; and rhabdomere. Part of myosin V complex; myosin VI complex; and myosin VII complex. Colocalizes with plasma membrane. Is expressed in several structures, including ganglia; head epidermis primordium; neurohemal organ; sensory nervous system primordium; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia 4; familial hypertrophic cardiomyopathy; long QT syndrome 14; long QT syndrome 15; and long QT syndrome 16. Orthologous to human CALM1 (calmodulin 1); CALM2 (calmodulin 2); and CALM3 (calmodulin 3).
FB Description
Calmodulin (Cam) encodes a Calcium-binding messenger protein. It acts as a part of the calcium signal transduction pathway and interacts with various target proteins such as kinases or phosphatases. It is involved in actin filament-based movement, mitotic spinde assembly, axon guidance, DNA damage response, autophagy, cell death, sensory perception, and muscle homeostasis.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23050
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
per page

    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
    No records match query. Try removing filters.
    Showing 0 - 0 of 0 rows
    per page

      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
      No records match query. Try removing filters.
      Showing 0 - 0 of 0 rows
      per page
        Download all Alleles/Variants for all genes of the species

        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
        No records match query. Try removing filters.
        Showing 0 - 0 of 0 rows
        per page

          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
          No records match query. Try removing filters.
          Showing 0 - 0 of 0 rows
          per page

            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
            Viewer Help
            12.260M12.262M12.264M12.266M12.268M12.270M12.272M12.274M12.276M12.278M

            Sequence Details

            Loading...

            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Cam molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
            No records match query. Try removing filters.
            Showing 0 - 0 of 0 rows
            per page

              Genetic Interactions

              Cam role
              Cam genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
              No records match query. Try removing filters.
              Showing 0 - 0 of 0 rows
              per page