Gene

exd

Species
Drosophila melanogaster
Symbol
exd
Name
extradenticle
Synonyms
  • anon-EST:fe1H3
  • anon-fast-evolving-1H3
Biotype
protein coding gene
Automated Description
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; protein heterodimerization activity; and transcription coactivator activity. Involved in several processes, including nervous system development; oenocyte development; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex and protein-DNA complex. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; head epidermis primordium; neuroblast NB5-6; and segmental subdivision of organ system. Human ortholog(s) of this gene implicated in congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay. Orthologous to several human genes including PBX1 (PBX homeobox 1) and PBX3 (PBX homeobox 3).
FB Description
extradenticle (exd) encodes a homeodomain transcription factor that is imported to the nuclueus upon binding the product of hth. The protein complex hth-exd are Hox cofactors but also have additional Hox-independent functions such as in antennal development, proximal appendages patterning, and cell division promotion of the undifferentiated eye field.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11850
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            15.9925M15.9930M15.9935M15.9940M15.9945M15.9950M15.9955M15.9960M15.9965M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            exd molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
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              Genetic Interactions

              exd role
              exd genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
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