Gene

E(z)

Species
Drosophila melanogaster
Symbol
E(z)
Name
Enhancer of zeste
Synonyms
  • CG6502
  • dE(z)
Biotype
protein coding gene
Automated Description
Enables histone H3K27 methyltransferase activity; histone H3K9 methyltransferase activity; and sequence-specific DNA binding activity. Involved in several processes, including regulation of gene expression; regulation of neuroblast proliferation; and syncytial blastoderm mitotic cell cycle. Located in nucleus. Part of ESC/E(Z) complex. Is expressed in several structures, including anterior endoderm; central brain primordium; embryonic/larval midgut primordium; head mesoderm; and male germline cell. Used to study syndromic intellectual disability. Human ortholog(s) of this gene implicated in several diseases, including Weaver syndrome; gastrointestinal system cancer (multiple); glioblastoma; hematologic cancer (multiple); and renal Wilms' tumor. Orthologous to human EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit) and EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit).
FB Description
Enhancer of zeste (E(z)) encodes the catalytic component of the Polycomb Repressive Complex 2 (PRC2) methyltransferase that methylates histone H3 lysine27. Together with PRC1, PRC2 silences developmental genes to determine specific differentiated cell identities.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45747
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abdominal tergite 4
abdominal tergite | ectopic
abnormal body color | adult stage
abnormal eye color
abnormal mitotic cell cycle
abnormal mitotic cell cycle | embryonic stage
abnormal mitotic cell cycle | recessive
abnormal mitotic cell cycle | somatic clone
abnormal neuroanatomy | somatic clone
abnormal size | larval stage
Showing 1 - 10 of 102 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

No mapped variant information available
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
E(z)15
  • E(z)[15]
  • l(3)NU808
allele
E(z)64
  • E(z)[64]
  • E(z)[S5]
allele
E(z)65
  • E(z)[1R1]
  • E(z)[65]
allele
E(z)67
  • E(z)[1R5]
  • E(z)[67]
allele
E(z)69
  • E(z)[1R7]
  • E(z)[69]
allele
E(z)50
  • E(z)[50]
  • l(3)US53
allele
E(z)12
  • E(z)[12]
  • l(3)MY939
allele
Yes
E(z)14
  • E(z)[14]
  • l(3)NH006
allele
Yes
E(z)33
  • E(z)[33]
  • l(3)PI1517
allele
E(z)39
  • E(z)[39]
  • l(3)PX811
allele
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Transgenic Alleles

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
10.6350M10.6355M10.6360M10.6365M10.6370M10.6375M10.6380M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions

E(z) role
E(z) genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
enhanced gene
ash1Drosophila melanogaster
enhancer gene
genetic enhancement
    PMID:11729158
    suppressed gene
    AsxDrosophila melanogaster
    suppressor gene
    genetic suppression
      PMID:11729158
      enhanced gene
      AsxDrosophila melanogaster
      enhancer gene
      genetic enhancement
        PMID:11729158
        enhanced gene
        aurADrosophila melanogaster
        enhancer gene
        genetic enhancement
          PMID:11729158
          enhanced gene
          brmDrosophila melanogaster
          enhancer gene
          genetic enhancement
            PMID:11729158
            enhancer gene
            cortoDrosophila melanogaster
            enhanced gene
            genetic enhancement
              PMID:9463384
              suppressor gene
              ctDrosophila melanogaster
              suppressed gene
              genetic suppression
                PMID:8842142
                enhanced gene
                domDrosophila melanogaster
                enhancer gene
                genetic enhancement
                  PMID:11262242
                  enhanced gene
                  E(Pc)Drosophila melanogaster
                  enhancer gene
                  genetic enhancement
                    PMID:11729158
                    suppressed gene
                    E(Pc)Drosophila melanogaster
                    suppressor gene
                    genetic suppression
                      PMID:11729158
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