Gene

Fas2

Species
Drosophila melanogaster
Symbol
Fas2
Name
Fasciclin 2
Synonyms
  • 1D4
  • Ab 1D4
Biotype
protein coding gene
Automated Description
Predicted to enable cell-cell adhesion mediator activity. Involved in several processes, including neuron development; regulation of tube size, open tracheal system; and synapse organization. Located in several cellular components, including distal axon; muscle cell postsynaptic specialization; and synaptic membrane. Is expressed in several structures, including neurohemal organ; neuron projection bundle; neurons; presumptive embryonic/larval system; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; bipolar disorder; drug dependence; middle cerebral artery infarction; and nicotine dependence. Orthologous to human NCAM1 (neural cell adhesion molecule 1) and NCAM2 (neural cell adhesion molecule 2).
FB Description
Fasciclin 2 (Fas2) encodes a member of the immunoglobulin superfamily of cell adhesion molecules, and functions during axon extension and imaginal disc growth. Fas2 promotes EGFR-dependent epithelial cell proliferation in imaginal discs at low and moderate expression levels, whereas it acts as an EGFR repressor at high expression levels.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10075
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
4.14M4.15M4.16M4.17M4.18M4.19M4.20M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions