Version: 8.0.0
Date: Tue Jan 28 2025
Fas2
Drosophila melanogasterFB:FBgn0000635
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Fas2

Species
Drosophila melanogaster
Symbol
Fas2
Name
Fasciclin 2
Synonyms
  • 1D4
  • Ab 1D4
Biotype
protein coding gene
Automated Description
Predicted to enable cell-cell adhesion mediator activity. Involved in several processes, including neuron development; regulation of tube size, open tracheal system; and synapse organization. Located in several cellular components, including distal axon; muscle cell postsynaptic specialization; and synaptic membrane. Is expressed in several structures, including neurohemal organ; neuron projection bundle; neurons; presumptive embryonic/larval system; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; bipolar disorder; drug dependence; middle cerebral artery infarction; and nicotine dependence. Orthologous to human NCAM1 (neural cell adhesion molecule 1) and NCAM2 (neural cell adhesion molecule 2).
FB Description
Fasciclin 2 (Fas2) encodes a member of the immunoglobulin superfamily of cell adhesion molecules, and functions during axon extension and imaginal disc growth. Fas2 promotes EGFR-dependent epithelial cell proliferation in imaginal discs at low and moderate expression levels, whereas it acts as an EGFR repressor at high expression levels.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10075
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Fas2 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Fas2 role
            Fas2 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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