Predicted to enable cell-cell adhesion mediator activity. Involved in several processes, including neuron development; regulation of tube size, open tracheal system; and synapse organization. Located in several cellular components, including distal axon; muscle cell postsynaptic specialization; and synaptic membrane. Is expressed in several structures, including neurohemal organ; neuron projection bundle; neurons; presumptive embryonic/larval system; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; bipolar disorder; drug dependence; middle cerebral artery infarction; and nicotine dependence. Orthologous to human NCAM1 (neural cell adhesion molecule 1) and NCAM2 (neural cell adhesion molecule 2).
FB Description
Fasciclin 2 (Fas2) encodes a member of the immunoglobulin superfamily of cell adhesion molecules, and functions during axon extension and imaginal disc growth. Fas2 promotes EGFR-dependent epithelial cell proliferation in imaginal discs at low and moderate expression levels, whereas it acts as an EGFR repressor at high expression levels.