Predicted to enable 3'-5' DNA helicase activity. Involved in response to UV and transcription initiation at RNA polymerase II promoter. Located in nucleus. Part of transcription factor TFIIH holo complex. Is expressed in adult head; organism; and wing disc. Used to study Cockayne syndrome and xeroderma pigmentosum. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; photosensitive trichothiodystrophy 2; trichothiodystrophy; xeroderma pigmentosum; and xeroderma pigmentosum group B. Orthologous to human ERCC3 (ERCC excision repair 3, TFIIH core complex helicase subunit).
FB Description
haywire (hay) encodes a ATP-dependent 3'-5' DNA helicase based on the similarity with the human gene XPB, which is a subunit of the DNA repair and basal transcription factor TFIIH. The product of hay contributes to response to UV and homeotic gene expression.