Gene

hay

Species
Drosophila melanogaster
Symbol
hay
Name
haywire
Synonyms
  • CG8019
  • DhR25
Biotype
protein coding gene
Automated Description
Predicted to enable 3'-5' DNA helicase activity. Involved in response to UV and transcription initiation at RNA polymerase II promoter. Located in nucleus. Part of transcription factor TFIIH holo complex. Is expressed in adult head; organism; and wing disc. Used to study Cockayne syndrome and xeroderma pigmentosum. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; photosensitive trichothiodystrophy 2; trichothiodystrophy; xeroderma pigmentosum; and xeroderma pigmentosum group B. Orthologous to human ERCC3 (ERCC excision repair 3, TFIIH core complex helicase subunit).
FB Description
haywire (hay) encodes a ATP-dependent 3'-5' DNA helicase based on the similarity with the human gene XPB, which is a subunit of the DNA repair and basal transcription factor TFIIH. The product of hay contributes to response to UV and homeotic gene expression.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11274
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
10.6315M10.6320M10.6325M10.6330M10.6335M

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions