Version: 8.0.0
Date: Tue Jan 28 2025
Hex-A
Drosophila melanogasterFB:FBgn0001186
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Hex-A

Species
Drosophila melanogaster
Symbol
Hex-A
Name
Hexokinase A
Synonyms
  • CG3001
  • DM1
Biotype
protein coding gene
Automated Description
Enables glucosamine kinase activity and hexokinase activity. Involved in canonical glycolysis and glucose 6-phosphate metabolic process. Predicted to be located in mitochondrial outer membrane. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including adult head; cuboidal/columnar epithelium; dorsal ectoderm; dorsal epidermis primordium; and embryonic epipharynx. Used to study glucose metabolism disease. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 4G; anemia (multiple); artery disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to several human genes including GCK (glucokinase).
FB Description
Hexokinase A (Hex-A) encodes an enzyme involved in hexose metabolism that catalyzes the phosphorylation of hexoses D-glucose, D-fructose and D-mannose to D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively. It mediates the initial step of glycolysis by catalyzing the phosphorylation of D-glucose to D-glucose 6-phosphate.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19443
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Hex-A molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Hex-A role
            Hex-A genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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