Version: 8.0.0
Date: Tue Jan 28 2025
Idh
Drosophila melanogasterFB:FBgn0001248
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Idh

Species
Drosophila melanogaster
Symbol
Idh
Name
Isocitrate dehydrogenase (NADP+)
Synonyms
  • CG7176
  • cIdh
Biotype
protein coding gene
Automated Description
Enables isocitrate dehydrogenase (NADP+) activity. Involved in cellular response to oxidative stress and isocitrate metabolic process. Is active in cytosol and mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic anal pad; germline cell; and gut section. Used to study D-2-hydroxyglutaric aciduria and cancer. Human ortholog(s) of this gene implicated in autoimmune disease; hematologic cancer (multiple); hepatocellular clear cell carcinoma; and high grade glioma (multiple). Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1).
FB Description
Isocitrate dehydrogenase (Idh) encodes a cytosolic enzyme that catalyzes the oxidative decarboxylation of isocitrate to 2-oxoglutarate, with the concomitant reduction of NADP[+] to NADPH. It functions, along with Men, G6pd, and Pgd, in a small network of NADP reducing enzymes.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11822
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            8.3565M8.3570M8.3575M8.3580M8.3585M8.3590M8.3595M8.3600M8.3605M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Idh molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              Idh role
              Idh genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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