Version: 8.0.0Date: Tue Jan 28 2025
Gene
dlg1
- Species
- Drosophila melanogaster
- Symbol
- dlg1
- Name
- discs large 1
- Synonyms
- 11
- anon-EST:Posey93
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable protein kinase binding activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; basal protein localization; and oogenesis. Located in several cellular components, including apicolateral plasma membrane; lateral plasma membrane; and tight junction. Is active in type Ib terminal bouton. Colocalizes with presynaptic membrane. Is expressed in several structures, including epithelial cell; eye photoreceptor cell; ganglia; neuron projection bundle; and synaptic neuropil domain. Used to study benign neoplasm; cancer; carcinoma; chromosome 3q29 microdeletion syndrome; and developmental disorder of mental health. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; invasive ductal carcinoma; and non-syndromic X-linked intellectual disability 90. Orthologous to several human genes including DLG1 (discs large MAGUK scaffold protein 1); DLG3 (discs large MAGUK scaffold protein 3); and DLG4 (discs large MAGUK scaffold protein 4).
- FB Description
- Not Available
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR23119
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Sequence Feature Viewer
- Genome location
- ChrX:11369665...11409776 + (40.11 kb)
- Assembly version
- R6
- Viewer Help
Data currently unavailable; sequence viewer under construction