Gene

eIF4A

Species
Drosophila melanogaster
Symbol
eIF4A
Name
eukaryotic translation initiation factor 4A
Synonyms
  • 2439
  • 9075
Biotype
protein coding gene
Automated Description
Enables SMAD binding activity. Involved in several processes, including female germ-line stem cell asymmetric division; pole cell formation; and regulation of alternative mRNA splicing, via spliceosome. Located in P granule and cytosol. Is expressed in several structures, including adult head; adult heart; embryonic/larval salivary gland; imaginal disc; and larval brain. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with hypotonia and speech delay. Orthologous to several human genes including EIF4A1 (eukaryotic translation initiation factor 4A1).
FB Description
eukaryotic translation initiation factor 4A (eIF4A) encodes an essential DEAD-box RNA helicase protein and a canonical translation initiation factor. It is a component of the eIF4F cap-binding complex that is essential for cap-dependent translation of mRNA.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24031
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
5.9820M5.9825M5.9830M5.9835M5.9840M5.9845M5.9850M5.9855M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions