Predicted to enable actin filament binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in several processes, including axon development; nuclear envelope budding; and positive regulation of filopodium assembly. Located in cytosol and nuclear lamina. Colocalizes with nuclear envelope. Is expressed in several structures, including adult head; anterior endoderm; dorsal pharyngeal muscle primordium; embryonic/larval midgut primordium; and larval muscle cell. Human ortholog(s) of this gene implicated in gastritis; immunodeficiency 71; myelodysplastic syndrome; and pancreatic cancer. Orthologous to human ARPC1A (actin related protein 2/3 complex subunit 1A) and ARPC1B (actin related protein 2/3 complex subunit 1B).
FB Description
Actin-related protein 2/3 complex, subunit 1 (Arpc1) encodes one of seven components of the highly conserved Arp2/3 complex. The Arp2/3 complex is required for many cellular and developmental processes requiring F-actin polymerization, including germline ring canal growth, embryonic cellularization, myoblast fusion, and endocytosis.