Gene

Arpc1

Species
Drosophila melanogaster
Symbol
Arpc1
Name
Actin-related protein 2/3 complex, subunit 1
Synonyms
  • 34Dd
  • ARC-P41
Biotype
protein coding gene
Automated Description
Predicted to enable actin filament binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in several processes, including axon development; nuclear envelope budding; and positive regulation of filopodium assembly. Located in cytosol and nuclear lamina. Colocalizes with nuclear envelope. Is expressed in several structures, including adult head; anterior endoderm; dorsal pharyngeal muscle primordium; embryonic/larval midgut primordium; and larval muscle cell. Human ortholog(s) of this gene implicated in gastritis; immunodeficiency 71; myelodysplastic syndrome; and pancreatic cancer. Orthologous to human ARPC1A (actin related protein 2/3 complex subunit 1A) and ARPC1B (actin related protein 2/3 complex subunit 1B).
FB Description
Actin-related protein 2/3 complex, subunit 1 (Arpc1) encodes one of seven components of the highly conserved Arp2/3 complex. The Arp2/3 complex is required for many cellular and developmental processes requiring F-actin polymerization, including germline ring canal growth, embryonic cellularization, myoblast fusion, and endocytosis.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10709
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
13.8280M13.8282M13.8284M13.8286M13.8288M13.8290M13.8292M13.8294M13.8296M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions