Predicted to be an extracellular matrix structural constituent. Involved in several processes, including dorsal trunk growth, open tracheal system; melanotic encapsulation of foreign target; and negative regulation of synaptic assembly at neuromuscular junction. Located in basement membrane and presynaptic periactive zone. Is expressed in several structures, including embryonic/larval midgut primordium; germ layer; glial cell; head epidermis primordium; and hemocyte. Human ortholog(s) of this gene implicated in bent bone dysplasia syndrome 2; familial nephrotic syndrome; junctional epidermolysis bullosa; and lung small cell carcinoma. Orthologous to several human genes including LAMA5 (laminin subunit alpha 5).