Gene

RpS3

Species
Drosophila melanogaster
Symbol
RpS3
Name
Ribosomal protein S3
Synonyms
  • 6779
  • CG6779
Biotype
protein coding gene
Automated Description
Enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity; oxidized purine DNA binding activity; and oxidized purine nucleobase lesion DNA N-glycosylase activity. A structural constituent of ribosome. Involved in DNA repair and negative regulation of neuron apoptotic process. Located in cytosolic ribosome and nuclear matrix. Is expressed in adult head; adult heart; organism; and ovary. Used to study intrinsic cardiomyopathy. Orthologous to human RPS3 (ribosomal protein S3).
FB Description
Ribosomal protein S3 (RpS3) encodes a component of the small subunit of cytoplasmic ribosomes, which translate mRNAs encoded by the nuclear genome. RpS3 is haploinsufficient - heterozygous mutants display the 'Minute' phenotype, characterized by a slower developmental rate and small adult bristles. The product of RpS3 also contains a DNA lyase activity and functions in DNA repair.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11760
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            23.3590M23.3592M23.3594M23.3596M23.3598M23.3600M23.3602M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            RpS3 molecule type
            Interactor gene
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              Genetic Interactions

              RpS3 role
              RpS3 genetic perturbation
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