Gene

Pu

Species
Drosophila melanogaster
Symbol
Pu
Name
Punch
Synonyms
  • CG9441
  • DGTPCH
Biotype
protein coding gene
Automated Description
Enables GTP cyclohydrolase I activity and GTP cyclohydrolase I regulator activity. Involved in several processes, including compound eye pigmentation; preblastoderm mitotic cell cycle; and pteridine biosynthetic process. Located in cytoplasm. Is expressed in several structures, including adult head; imaginal disc; larval ventral nerve cord; and oocyte. Human ortholog(s) of this gene implicated in several diseases, including BH4-deficient hyperphenylalaninemia B; diabetic angiopathy; movement disease (multiple); sickle cell anemia; and type 2 diabetes mellitus. Orthologous to human GCH1 (GTP cyclohydrolase 1).
FB Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11109
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
21.176M21.177M21.178M21.179M21.180M21.181M21.182M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions