Gene

ru

Species
Drosophila melanogaster
Symbol
ru
Name
roughoid
Synonyms
  • CG1214
  • rho-3
Biotype
protein coding gene
Automated Description
Enables serine-type endopeptidase activity. Involved in several processes, including compound eye morphogenesis; epidermal growth factor receptor ligand maturation; and epithelial cell migration, open tracheal system. Located in apical part of cell; bounding membrane of organelle; and endoplasmic reticulum. Is expressed in several structures, including adult heart; embryonic head sensory system; organism subdivision; and sensory nervous system primordium. Orthologous to several human genes including RHBDL1 (rhomboid like 1) and RHBDL3 (rhomboid like 3).
FB Description
roughoid (ru) encodes an intra-membrane serine protease localized in the endoplasmic reticulum. It processes Egfr ligands in specific tissues, most notably the eye.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45840
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            1.372M1.374M1.376M1.378M1.380M1.382M1.384M1.386M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ru molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
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              Genetic Interactions

              ru role
              ru genetic perturbation
              Interactor gene
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              Interactor role
              Interactor genetic perturbation
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              Phenotype or trait
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