Version: 8.0.0
Date: Tue Jan 28 2025
sd
Drosophila melanogasterFB:FBgn0003345
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

sd

Species
Drosophila melanogaster
Symbol
sd
Name
scalloped
Synonyms
  • anon-EST:Liang-2.14
  • CG8544
Biotype
protein coding gene
Automated Description
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coregulator binding activity. Involved in several processes, including imaginal disc-derived appendage morphogenesis; negative regulation of neuroblast proliferation; and regulation of DNA-templated transcription. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including ganglia; imaginal disc; myoblast; sense organ; and somatic muscle cell. Human ortholog(s) of this gene implicated in Sveinsson chorioretinal atrophy. Orthologous to several human genes including TEAD3 (TEA domain transcription factor 3).
FB Description
scalloped (sd) encodes a DNA binding protein of the TEAD class. It requires co-factor proteins ,such as the products of vg and yki, to act as a transcription factor, and is modified by Hippo and Wingless signalling. It is involved in wing and neuronal specification.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11834
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
            Viewer Help
            15.806M15.808M15.810M15.812M15.814M15.816M15.818M15.820M15.822M15.824M15.826M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            sd molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              sd role
              sd genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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