Version: 8.0.0
Date: Tue Jan 28 2025
Sh
Drosophila melanogasterFB:FBgn0003380
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Sh

Species
Drosophila melanogaster
Symbol
Sh
Name
Shaker
Synonyms
  • BcDNA:GH03046
  • CG12348
Biotype
protein coding gene
Automated Description
Enables voltage-gated monoatomic cation channel activity. Involved in several processes, including mating behavior, sex discrimination; proboscis extension reflex; and regulation of synaptic activity. Located in membrane. Part of voltage-gated potassium channel complex. Is expressed in several structures, including adult antennal nerve; adult head; adult somatic muscle cell; mushroom body; and synaptic neuropil domain. Used to study epilepsy and episodic ataxia type 1. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 32; episodic ataxia type 1; familial atrial fibrillation; and pulmonary hypertension. Orthologous to several human genes including KCNA2 (potassium voltage-gated channel subfamily A member 2) and KCNA3 (potassium voltage-gated channel subfamily A member 3).
FB Description
Shaker (Sh) encodes the structural alpha subunit of a voltage-gated potassium channel. It plays a key role in maintaining electrical excitability in neurons and muscle cells, as well as regulating neurotransmitter release at the synapse.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11537
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Sh molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Sh role
            Sh genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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