Predicted to enable cytoskeletal protein binding activity. Involved in embryonic development via the syncytial blastoderm; establishment of epithelial cell apical/basal polarity; and eye photoreceptor cell development. Located in apical junction complex; basolateral plasma membrane; and nuclear envelope. Is expressed in larval tracheal system. Orthologous to human EPB41L4B (erythrocyte membrane protein band 4.1 like 4B) and EPB41L5 (erythrocyte membrane protein band 4.1 like 5).
FB Description
yurt (yrt) encodes a membrane-associated protein. It contributes to apical-basal polarity and permeability of septate junctions. In differentiating epithelial cells, it counteracts apical polarity proteins to sustain lateral membrane stability and apical-basal polarity. In fully differentiated cells, the product of yrt acts as a negative regulatory component of the crb complex and limits apical membrane growth.