Version: 8.0.0
Date: Tue Jan 28 2025
G6pd
Drosophila melanogasterFB:FBgn0004057
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

G6pd

Species
Drosophila melanogaster
Symbol
G6pd
Name
Glucose-6-phosphate dehydrogenase
Synonyms
  • CG12529
  • G-6-PD
Biotype
protein coding gene
Automated Description
Enables glucose-6-phosphate dehydrogenase activity. Involved in pentose-phosphate shunt, oxidative branch. Predicted to be active in cytosol. Is expressed in adult fat body and adult head. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase).
FB Description
Glucose-6-phosphate dehydrogenase (G6pd) encodes a cytosolic enzyme that catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconate with the concomitant reduction of NADP+ to NADPH in the oxidative branch of the pentose phosphate pathway.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23429
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
            Viewer Help
            19.6675M19.6680M19.6685M19.6690M19.6695M19.6700M19.6705M19.6710M19.6715M19.6720M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            G6pd molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              G6pd role
              G6pd genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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