Gene

nAChRβ2

Species
Drosophila melanogaster
Symbol
nAChRβ2
Name
nicotinic Acetylcholine Receptor beta2
Synonyms
  • Acr96Ac
  • AcrF
Biotype
protein coding gene
Automated Description
Predicted to enable acetylcholine-gated monoatomic cation-selective channel activity. Involved in cholinergic synaptic transmission and response to insecticide. Predicted to be located in postsynaptic membrane. Predicted to be part of acetylcholine-gated channel complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in adult head; lobula; lobula plate; medulla; and transmedullary neuron Tm2. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; autosomal dominant nocturnal frontal lobe epilepsy (multiple); congenital myasthenic syndrome (multiple); gastrointestinal system cancer (multiple); and respiratory system cancer (multiple). Orthologous to several human genes including CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).
FB Description
nicotinic Acetylcholine Receptor beta2 (nAChRbeta2) encodes a subunit of the nicotinic acetylcholine receptor, which is part of the superfamily of ligand-gated ion channels. These channels open to facilitate the passage of cations across synaptic membranes in response to the binding of their native ligand, acetylcholine. Mutations in nAChRbeta2 have been associated with resistance phenotypes to several neonicotinoid insecticides.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR18945
No data available
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Paralogy

Function - GO Annotations

Pathways

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Phenotypes

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    Disease Associations

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      Alleles and Variants

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        Transgenic Alleles

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        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            24.510M24.511M24.512M24.513M24.514M24.515M

            Sequence Details

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            Expression

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            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            nAChRβ2 molecule type
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              Genetic Interactions

              nAChRβ2 role
              nAChRβ2 genetic perturbation
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