Gene

Csp

Species
Drosophila melanogaster
Symbol
Csp
Name
Cysteine string protein
Synonyms
  • ab49
  • anon-WO02059370.50
Biotype
protein coding gene
Automated Description
Involved in exocytosis; neuron cellular homeostasis; and regulation of neuromuscular synaptic transmission. Located in synaptic vesicle; type Ib terminal bouton; and type Is terminal bouton. Is expressed in several structures, including anterior-posterior subdivision of organism; neuromuscular junction; photoreceptor neurons; somatic muscle cell; and synaptic neuropil domain. Used to study neuronal ceroid lipofuscinosis 4. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 4. Orthologous to human DNAJC5 (DnaJ heat shock protein family (Hsp40) member C5) and DNAJC5B (DnaJ heat shock protein family (Hsp40) member C5 beta).
FB Description
Cysteine string protein (Csp) encodes a synaptic vesicle-associated co-chaperone of Hsc70 that is vital for presynaptic proteostasis and maintenance of synaptic function. The substartes of the product of Csp include SNARE proteins and the product of shi, which mediate synaptic vesicle exo- and endocytosis respectively.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR44027
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

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Phenotypes

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    Disease Associations

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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            Sequence Details

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            Expression

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            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Csp molecule type
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              Genetic Interactions

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