Gene

Ser

Species
Drosophila melanogaster
Symbol
Ser
Name
Serrate
Synonyms
  • Bd
  • Beaded
Biotype
protein coding gene
Automated Description
Enables Notch binding activity; glycosphingolipid binding activity; and receptor ligand activity. Involved in several processes, including lateral inhibition; post-embryonic animal morphogenesis; and regionalization. Located in several cellular components, including apical cortex; apical plasma membrane; and axolemma. Is expressed in several structures, including dorsal thoracic disc primordium; epithelium; gut section; imaginal disc; and organism subdivision. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in Alagille syndrome; congenital heart disease (multiple); multiple sclerosis; and neuromuscular disease (multiple). Orthologous to human JAG1 (jagged canonical Notch ligand 1) and JAG2 (jagged canonical Notch ligand 2).
FB Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24044
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
27.174M27.176M27.178M27.180M27.182M27.184M27.186M27.188M27.190M27.192M27.194M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions