Version: 8.0.0
Date: Tue Jan 28 2025
5-HT7
Drosophila melanogasterFB:FBgn0004573
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

5-HT7

Species
Drosophila melanogaster
Symbol
5-HT7
Name
5-hydroxytryptamine (serotonin) receptor 7
Synonyms
  • 5-HT-7
  • 5-HT-dro
Biotype
protein coding gene
Automated Description
Enables G protein-coupled serotonin receptor activity. Involved in female mating behavior; male courtship behavior; and serotonin receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in dendrite and plasma membrane. Is expressed in several structures, including adult ellipsoid body ring neurons; brain; ellipsoid body layer; synaptic neuropil domain; and ventral nerve cord. Human ortholog(s) of this gene implicated in alcohol use disorder. Orthologous to human HTR7 (5-hydroxytryptamine receptor 7).
FB Description
5-hydroxytryptamine (serotonin) receptor 7 (5-HT7) encodes a 5-hydroxytryptamine (serotonin) GPCR that belongs to the Class A GPCR family. They bind and transmit the signal from the neurotransmitter 5-HT (serotonin). The family can be subdivided into several subclasses based on pharmacology, signal transduction and structure. There are 5 genes encoding serotonin receptors in the Drosophila melanogaster genome: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT7. The product of 5-HT7 is involved in olfactory learning and memory, and courtship behaviors.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24247
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            30.970M30.975M30.980M30.985M30.990M30.995M31.000M31.005M31.010M31.015M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            5-HT7 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              5-HT7 role
              5-HT7 genetic perturbation
              Interactor gene
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