Gene

tws

Species
Drosophila melanogaster
Symbol
tws
Name
twins
Synonyms
  • 1466/06
  • 2414
Biotype
protein coding gene
Automated Description
Enables protein phosphatase regulator activity. Involved in several processes, including maintenance of neuroblast polarity; positive regulation of signal transduction; and regulation of cell cycle process. Located in cytosol and nucleus. Is expressed in several structures, including adult optic lobe; embryonic/larval hindgut; female germline cell; gonad; and imaginal disc. Used to study autosomal dominant cerebellar ataxia. Human ortholog(s) of this gene implicated in Alzheimer's disease; brain disease; breast cancer; and spinocerebellar ataxia type 12. Orthologous to several human genes including PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta).
FB Description
twins (tws) encodes a regulatory subunit of protein phosphatase 2A (PP2A) and is involved in many developmental processes and signaling pathways.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11871
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
10.128M10.130M10.132M10.134M10.136M10.138M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions