Gene

ey

Species
Drosophila melanogaster
Symbol
ey
Name
eyeless
Synonyms
  • CG1464
  • DPax-6
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including adult walking behavior; nervous system development; and regulation of insulin-like growth factor receptor signaling pathway. Predicted to be located in nucleus. Is expressed in several structures, including intrinsic neurons; neuroblasts; neuromere; synaptic neuropil domain; and synaptic neuropil subdomain. Human ortholog(s) of this gene implicated in diabetic ketoacidosis; maturity-onset diabetes of the young type 9; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human PAX4 (paired box 4).
FB Description
eyeless (ey) encodes a transcription factor that is involved in eye development as part of the retinal determination gene network, and contributes to brain formation.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45636
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
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      Alleles and Variants

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      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ey molecule type
            Interactor gene
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              Genetic Interactions

              ey role
              ey genetic perturbation
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