Enables receptor ligand activity. Involved in several processes, including determination of muscle attachment site; neuron projection morphogenesis; and positive regulation of cell projection organization. Located in dendrite and extracellular region. Is expressed in several structures, including A1-7 lateral transverse muscle cell; head segment; neuromere; neuron projection bundle; and ventral thoracic disc primordium. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 1. Orthologous to human WNT5A (Wnt family member 5A) and WNT5B (Wnt family member 5B).
FB Description
Wnt oncogene analog 5 (Wnt5) encodes a member of the Wnt gene family and acts as a signalling ligand for the Ryk family of receptor tyrosine kinase-related Wnt receptors. Among other processes, the product of Wnt5 contributes to repulsive embryonic axon pathfinding, mushroom body growth and antennal lobe patterning.