Gene

Sply

Species
Drosophila melanogaster
Symbol
Sply
Name
Sphingosine-1-phosphate lyase
Synonyms
  • anon-WO0142479.5
  • CG8946
Biotype
protein coding gene
Automated Description
Enables sphinganine-1-phosphate aldolase activity. Involved in adult somatic muscle development and sphingolipid catabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; extraembryonic structure; and gut section. Used to study Charcot-Marie-Tooth disease; nephrotic syndrome; and obesity. Human ortholog(s) of this gene implicated in nephrotic syndrome type 14. Orthologous to human SGPL1 (sphingosine-1-phosphate lyase 1).
FB Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR42735
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
17.0885M17.0890M17.0895M17.0900M17.0905M17.0910M17.0915M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions