Gene

CG10939

Species
Drosophila melanogaster
Symbol
CG10939
Name
Not Available
Synonyms
  • CG10939
  • l(2)06373
Biotype
protein coding gene
Automated Description
Enables molecular adaptor activity. Involved in several processes, including epithelial structure maintenance; positive regulation of cell-cell adhesion; and regulation of renal system process. Is active in cytoplasmic side of apical plasma membrane. Is expressed in several structures, including adult head; anlage in statu nascendi; embryonic/larval midgut primordium; gut section; and head epidermis primordium. Used to study hypophosphatemic nephrolithiasis/osteoporosis 2. Human ortholog(s) of this gene implicated in hypophosphatemic nephrolithiasis/osteoporosis 2. Orthologous to human NHERF1 (NHERF family PDZ scaffold protein 1) and NHERF2 (NHERF family PDZ scaffold protein 2).
FB Description
CG10939 encodes a protein that functions as a scaffold linking the plasma membrane and cytoskeletal linker proteins encoded by Mer and Moe. Via interaction with the products of Slik and flw, it regulates the activity of the products of Mer and Moe in epithelial cell adhesion.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14191
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensNHERF13 of 9YesYes   
Homo sapiensNHERF23 of 9YesYes   
Mus musculusNherf26 of 9YesYes   
Mus musculusNherf15 of 9NoYes   
Rattus norvegicusNherf25 of 9YesYes   
Rattus norvegicusNherf14 of 9NoYes   
Xenopus tropicalisnherf15 of 9YesYes   
Xenopus tropicalisnherf23 of 9YesYes   
Danio rerionherf1a4 of 10YesYes  
Danio rerionherf1b4 of 10YesYes  
Caenorhabditis elegansnrfl-13 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal smell perception
adult Malpighian tubule
filamentous actin | somatic clone
follicle cell | somatic clone
lethal | recessive
viable
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
R6
Viewer Help
17.395M17.396M17.397M17.398M17.399M17.400M17.401M17.402M17.403M17.404M17.405M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
CG10939BG01295
  • BG01295
  • CG10939[BG01295]
allele
Yes
CG109395a
  • CG10939[5a]
  • Sip1[5a]
allele
YesYes
CG1093906373
  • CG10939[06373]
  • l(2)06373
allele with one associated variant
insertion
  • 5 prime UTR variant
Yes
CG10939DG19102
  • CG10939[DG19102]
  • Sip1[DG19102]
allele with one associated variant
insertion
  • 5 prime UTR variant
CG10939MI11896
  • CG10939[MI11896]
  • Sip1[MI11896]
allele with one associated variant
insertion
  • intron variant
CG10939NP5143
  • CG10939[NP5143]
  • Sip1[NP5143]
allele with one associated variant
insertion
  • 5 prime UTR variant
CG10939f04862
  • CG10939[f04862]
  • Sip1[f04862]
allele with one associated variant
insertion
  • 5 prime UTR variant
CG10939c01824
  • CG10939[c01824]
  • Sip1[c01824]
allele with one associated variant
insertion
  • 5 prime UTR variant
CG10939EP2037
  • CG10939[EP2037]
  • Sip1[EP2037]
allele with one associated variant
CG10939f02074
  • CG10939[f02074]
  • Sip1[f02074]
allele with one associated variant
insertion
  • intron variant
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Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogasterCG10939GD7135
  • UASt
Drosophila melanogasterCG10939HMC06036
  • UAS
Yes
Drosophila melanogasterCG10939KK101439
  • UASt
Drosophila melanogasterCG10939NIG.10939R
  • UASt
Drosophila melanogasterCG10939TKO.GS05536
Drosophila melanogasterCG10939U6.NIG.sgRNA
Drosophila melanogasterCG10939UAS.Tag:MYC
  • UASt
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Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
17.395M17.396M17.397M17.398M17.399M17.400M17.401M17.402M17.403M17.404M17.405M

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

10 interactor genes based on 15 annotations
CG10939 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
CG4853Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
flwDrosophila melanogaster
protein
  • pull down
PMID:22133918
protein
MerDrosophila melanogaster
protein
  • pull down
PMID:25204795
protein
MerDrosophila melanogaster
protein
  • anti tag coimmunoprecipitation
PMID:25204795
protein
MerDrosophila melanogaster
protein
  • anti tag coimmunoprecipitation
PMID:25204795
protein
MoeDrosophila melanogaster
protein
  • two hybrid
PMID:20215404
protein
MoeDrosophila melanogaster
protein
  • anti tag coimmunoprecipitation
PMID:20215404
protein
MoeDrosophila melanogaster
protein
  • anti tag coimmunoprecipitation
PMID:20215404
protein
Rap2lDrosophila melanogaster
protein
  • two hybrid
PMID:15710747
protein
RpS7Drosophila melanogaster
protein
  • two hybrid array
PMID:19079254
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Genetic Interactions

CG10939 role
CG10939 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
enhanced gene
MoeDrosophila melanogaster
enhancer gene
genetic enhancement
    PMID:20215404
    suppressed gene
    Rho1Drosophila melanogaster
    suppressor gene
    genetic suppression
      PMID:20215404
      Showing 1 - 2 of 2 rows
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