Gene

blw

Species
Drosophila melanogaster
Symbol
blw
Name
bellwether
Synonyms
  • A2(2nd)27
  • alpha subunit of ATP synthase
Biotype
protein coding gene
Automated Description
Predicted to enable ADP binding activity and ATP binding activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Involved in electron transport chain and lipid storage. Located in mitochondrion. Is expressed in adult head; adult heart; adult hemolymph; germline cell; and wing disc. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 22; mitochondrial complex V (ATP synthase) deficiency nuclear type 4A; and mitochondrial complex V (ATP synthase) deficiency nuclear type 4B. Orthologous to human ATP5F1A (ATP synthase F1 subunit alpha).
FB Description
bellwether (blw) encodes the alpha subunit of the mitochondrial F1F0 ATP synthase complex (complex V), the final enzyme of the oxidative phosphorylation pathway. Complex V catalyzes the synthesis of ATP from ADP and inorganic phosphate using the electrochemical proton gradient across the inner mitochondrial membrane.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR48082
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
22.7995M22.8000M22.8005M22.8010M22.8015M22.8020M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions