Gene

Irbp

Species
Drosophila melanogaster
Symbol
Irbp
Name
Inverted repeat-binding protein
Synonyms
  • CG5247
  • DmKu70
Biotype
protein coding gene
Automated Description
Enables DNA binding activity. Involved in double-strand break repair via nonhomologous end joining and telomere maintenance. Part of Ku70:Ku80 complex. Is expressed in organism. Orthologous to human XRCC6 (X-ray repair cross complementing 6).
FB Description
Inverted repeat-binding protein (Irbp) encodes a protein that, together with the product of Ku80, forms part of the Ku protein complex, which is involved in double-strand break repair via non-homologous end joining and telomere maintenance.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12604
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
            Viewer Help
            11.4102M11.4104M11.4106M11.4108M11.4110M11.4112M11.4114M11.4116M11.4118M11.4120M11.4122M11.4124M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Irbp molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              Irbp role
              Irbp genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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