Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in mitotic G2 DNA damage checkpoint signaling and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in nucleus. Is expressed in organism. Orthologous to human DTL (denticleless E3 ubiquitin protein ligase homolog).
FB Description
lethal-(2)-denticleless (l(2)dtl) encodes the Cdt2 protein, which functions as a substrate receptor for a Cul4-based E3 ubiquitin ligase. The ubiquitylation and subsequent destruction of Cdt2 substrates depends on DNA synthesis that occurs during S phase or after DNA damage and includes proteins involved in genome function and maintenance.